Brief

Deebo Samuel leaves 49ers game with hamstring injury after costly fumble

Samuel's injury and turnover could affect San Francisco's NFC West push.

By Felo News Desk · Published Mon, 12 Oct 2026 12:12:27 GMT

Deebo Samuel suffered a right hamstring injury late in the third quarter of the San Francisco 49ers' 32-29 loss to the Seattle Seahawks on Sunday, Oct. 11, 2026, and fumbled the ball as he went down, according to the New York Post.

What happened

Quarterback Brock Purdy took a shotgun snap and threw a short pass to Samuel, who sprinted toward the left sideline. As he reached the edge of the field, his right hamstring gave out, causing him to collapse and lose control of the football. The fumble gave Seattle another possession, which they turned into three points. The turnover was the seventh combined turnover of the game and the second consecutive 49ers possession to end in a turnover, following an earlier Purdy interception that led to a 16‑yard touchdown pass to Seahawks receiver Jaxon Smith‑Njigba.

What the reports add

The Post notes that Samuel limped off the field and was ruled out for the remainder of the game. Minutes later, the 49ers also lost wide receiver Jacob Cowing to an ankle injury. The severity of Samuel’s hamstring strain was described as “unknown,” with further evaluation and possible imaging expected to determine whether it is a mild strain or a more serious injury.

What was said

The article contains no direct quotations from players or coaches.

How it came about

Earlier this season, the 49ers have dealt with injuries to key players, including a calf strain to defensive end Nick Bosa that kept him out of the previous week’s game (Felo News). The team’s recent turnover issues were highlighted in a Felo recap of the same matchup, which described four Seattle turnovers that directly led to 49ers scores (Felo News).

Key facts

• Deebo Samuel suffered a right hamstring injury and fumbled the ball in the third quarter of the 49ers' 32-29 loss to the Seahawks on Oct. 11, 2026. (nypost.com)
• The fumble was the seventh combined turnover of the game and gave Seattle three points. (nypost.com)
• Jacob Cowing also left the game with an ankle injury minutes after Samuel's exit. (nypost.com)

Sources

• [1] nypost.com — originally reported as “49ers’ nightmare gets worse as Deebo Samuel goes down in disastrous sequence against Seahawks”